Having a lot of Zan moves would be it; Medusa in SMT IV was pretty much no more or less difficult than Minotaur, really. Force tends to be the least represented element in any given party I use in any given SMT game really (except Nocturne, where Tornado has the highest damage output of anything you get for a long time), so she was a road block of greater difficulty than Minotaur. Of course, both of them are undeniably the hardest bosses in the game until like, Kenji lol. That game's balance was so unrelentingly awful.
Meanwhile in SMT4A, Medusa is the exact same boss who comes in when you're over level 30 and thus have enough MP to reliably buff/debuff, and have just been given a partner that nulls her Marin Karin. lolwhoops
i didn't even know she had marin karin this time around so double whoops